Identification of low abundant protein biomarkers using blood as the starting sample

Scientific Essay from the year 2010 in the subject Biology - Micro- and Molecular Biology, grade: 78, University of Nottingham, course: Proteomics, language: English, abstract: Blood is the most popular biofluid used in proteomics to identify disease biomarkers. The potential of blood plasma or serum in diagnosis can be realized by the large amount of research and money spend on their study.
Interestingly, blood is a treasure trove of disease biomarkers. Every cell in the body leave a record of its physiological state in the form of waste or signal molecules in the products that it sheds to blood.Hence blood samples can reveal lot about physiology and pathological states of body. This review describes the various methods involved in the identification of low abundant protein biomarkers in blood.