Alagille Syndrome: Pathogenesis and Clinical Management

1 The Alagille Syndrome: Overview and IntroductionDavid Piccoli
2 Bile Duct Development and the Notch Signaling PathwayStacey S. Huppert, Kathleen M. Campbell
3 Genetics of Alagille SyndromeMelissa A. Gilbert, Nancy B. Spinner
4 Liver Disease in Alagille SyndromeAlyssa Kriegermeier, Andrew Wehrman, Binita M. Kamath, Kathleen M. Loomes
5 Transplant Considerations in Alagille SyndromeEvelyn Hsu, Elizabeth Rand
6 Cardiac, Aortic, and Pulmonary Vascular Involvement in Alagille SyndromeJustin T. Tretter, Doff B. McElhinney
7 Vascular Manifestations in Alagille SyndromeShannon M. Vandriel, Rebecca N. Ichord, Binita M. Kamath
8 The Renal Sequelae of Alagille Syndrome as a Product of Altered Notch Signaling During Kidney DevelopmentRené Romero
9 Skeletal Involvement in Alagille SyndromeYadav Wagley, Troy Mitchell, Jason Ashley, Kathleen M. Loomes, Kurt Hankenson
10 Immune Dysregulation in Alagille Syndrome: A Feature of the Evolving PhenotypeAlastair Baker
11 Health-Related Quality of Life and Neurocognition in Alagille SyndromeSaeed Mohammad, Estella M Alonso
12 Future Therapeutic Approaches for Alagille Syndrome Emma R. Andersson