Mechanisms of Cerebral Hypoxia and Stroke

Adaptation in Diving Vertebrates.- Inborn resistance to hypoxia and the O2-dependence of metabolism.- Brain vulnerability and survival during anoxia: protective strategies of hypoxia-resistant vertebrates.- General Pathology.- Early and late neuronal damage following cerebral ischemia.- Selective neuronal cell death after transient forebrain ischemia in the mongolian gerbil.- Possible implications of ischemic damage to dentate hilar somatostatin neurons in the rat.- Regulation of glutamate receptors in hippocampus after cerebral ischemia.- Role of edema in the pathophysiology of ischemic injury.- Acidosis-related brain damage immediate and delayed events.- Pathology of ischaemic brain damage: implications for therapy.- Ischemic damage of rat hippocampus and basal ganglia: light microscopical and biochemical changes.- Pathophysiology.- Physiological aspects of brain ischaemia in the experimental primate and man.- The dependency of cerebral ischemic damage on duration and severity of ischemia: studies of single cell activity and multimodality evoked responses.- Microcirculation and metabolism in reversible and irreversible cerebral ischemia.- Cerebral blood flow and its responsiveness to CO2 after traumatic and ischemic brain injuries.- The correlation between electrophysiological parameters (EEG, DC potential and tissue available O2) and regional metabolites (pH, ATP, glucose, NADH, K) after 45 min middle cerebral artery occlusion and 3 hours recirculation in cats.- Cerebral hypoxia during repetitive seizures.- Microcirculation, NAD/NADH fluorescence, extracellular potassium and glucose metabolism changes in focal cerebral ischemia.- Neurons, glia and ions in hypoxia, hypercapnia and acidosis.- Effects of anoxia on nerve cell function.- Reversible synaptic blockade caused by hypoxia of moderate degree in hippocampal tissue slices.- Anoxia reversibly inactivates hippocampal calcium currents.- Reversibility of neuronal function of hippocampal slice during deprivation of oxygen and/or glucose.- The effect of hypoxia on hippocampal neurones and its prevention by Ca2+-antagonists.- Anoxia in CA1 pyramidal cells: ionic and metabolic factors contributing to recovery of ion transport and synaptic transmission.- Long-term inhibition of synaptic transmission and macromolecular synthesis following anoxia in the rat hippocampal slice: interaction between Ca2+ and NMDA receptors.- Early alterations in striatal and hippocampal impedance and extracellular amino acids by cardiac arrest in freely moving rats.- Susceptibility to spreading depression and anoxia: regional differences and drug control.- Blood flow and metabolism in cortical spreading depression.- Dynamics of volatile buffers in brain cells during spreading depression.- The role of spreading depression-like hypoxic depolarization in irreversible neuron damage, and its prevention.- NMDA antagonists inhibit cortical spreading depression, but accelerate the onset of neuronal depolarization induced by asphyxia.- Does Leao s spreading depression cause irreversible brain damage?.- Electrophysiological and biochemical events in the isolated perfused rat brain under ischemia and reperfusion.- Neurotransmitter modulation of neuronal damage following cerebral ischemia: Effects on protein ubiquitination.- Detection of free radicals in cerebral tissue and their relation to cerebral hypoxia/ischemia.- Pharmacology.- The limits of reversibility from ischemic cerebral insult and our method of prolonging cerebral survival.- Excitatory amino acid neurotransmission and protection against ischaemic brain damage.- Excitatory amino acid and purinergic transmitter involvement in ischemia-induced selective neuronal death.- Protection of hippocampal neurons from ischemic insult in vitro by acidic amino acid antagonists.- Magnesium inhibits ischemia-induced calcium accumulation in hilar neurones: possible effect of NMDA-receptor.- Dopamine and the susceptibility of striatal neurons to ischemia.- Effects