Comprehensive Enzyme Kinetics

1. Introduction. 2. Chemical kinetics. 3. Kinetics of monosubstrate reactions. 4. Derivations of rate equations. 5. Linear inhibition. 6. Hyperbolic and parabolic inhibition. 7. Enzyme activation. 8. Kinetics of rapid equilibrium bisubstrate reactions. 9. Steady state kinetics of bisubstrate reactions. 10. Kinetic analysis of bisubstrate mechanisms. 11. Substrate inhibition and mixed dead-end and product inhibition. 12. Kinetics of trisubstrate reactions. 13. Cooperative and allosteric effects. 14. The pH dependence of enzyme catalysis. 15. Effects of temperature on enzyme reactions. 16. Isotope exchange. 17. Solvent and kinetic isotope effects. 18. Statistical analysis of initial rate and binding data. Subject index.