Tetrapyrroles: Birth, Life and Death

Preface.- 1. An Historical Introduction to Porphyrin and Chlorophyll Synthesis.- 2. Biosynthesis of 5-Aminolevulinic Acid.- 3. 5-Aminolaevulinic Acid Dehydratase, Porphobilinogen Deaminase and Uroporphyrinogen III Synthase.- 4. Transformation of Uroporphyrinogen III into Protohaem.- 5. Inherited Disorders of Haem Synthesis: The Human Porphyrias.- 6. Heme Degradation: Mechanistic and Physiological Implications.- 7. Regulation of Mammalian Heme Biosynthesis.- 8. Tetrapyrroles in Photodynamic Therapy.- 9. Heme Transport and Incorporation into Proteins.- 10. Heme and Hemoproteins.- 11. Novel Heme-Protein Interactions-Some More Radical Than Others.- 12.Synthesis and Role of Bilins in Photosynthetic Organisms.- 13. Phytochromes: Bilin-Linked Photoreceptors in Bacteria and Plants.- 14. Biosynthesis of Chlorophyll and Bacteriochlorophyll.- 15. Regulation of Tetrapyrrole Synthesis in Higher Plants.- 16. Regulation of the Late Steps of Chlorophyll Biosynthesis.- 17. Chlorophyll Breakdown.- 18. Vitamin B12; Biosynthesis of the Corrin Ring.- 19. Conversion of Cobinamide into Coenzyme B12.- 20. The Regulation of Cobalamin Biosynthesis.- 21. Coenzyme B12-Catalyzed Radical Isomerizations.- 22. Biosynthesis of Siroheme and Coenzyme F430.- 23. Role of Coenzyme F430 in Methanogenesis.- 24. The Role of Siroheme in Sulfite and Nitrite Reductases.- 25. The Role of Heme d1 in Denitrification.