Studies on Periodontal Disease

Part I: Oxidative stress in periodontal diseases (basic science).- 1. Reactive oxygen species and antioxidant systems in periodontal disease.- 2. The role of protein oxidative modification in periodontal diseases.- 3. Association between oxidative stress and periodontal diseases in animal model studies.- 4. Expression of reactive oxygen species and junctional and pocket epithelium.- 5. DNA damage caused by oral malodorous compounds in periodontal cells in vitro .- 6. Apoptotic pathways triggered by oral malodorous compounds in periodontal cells.- 7. The role of p53 in carcinogenesis and apoptosis in oral tissues.- 8. Physiological roles of a periodontopathic bacterial membrane-bound quinol peroxidase.- Part II: Oxidative stress in periodontal diseases (clinical studies).- 9. Periodontitis and oxidative stress: Human clinical studies.- 10. Effects of periodontal therapy on circulating oxidative stress.- 11. Roles of HMGB1 in periodontal disease.- 12. The inflammation as the connecting link between systemic diseases and periodontal diseases.- 13. Periodontitis and atherosclerosis.- 14. Periodontitis and liver diseases.- 15. Oxidative stress and Periodontal disease in Down syndrome.- Part IV: Future strategies (control of ROS, roles of nutrition/antioxidants and application to dentistry).- 16. New theories and their clinical relevance about the onset and development of periodontal diseases.- 17. The role of nutrition in periodontal diseases.- 18. Effects of antioxidants on periodontal disease.- 19. Role of vitamin C and vitamin E in periodontal disease.- 20. Salivary biomarkers of oxidative stress associated with periodontal diseases.