Alcoholism: A Molecular Perspective

Pathways of ethanol metabolism and related pathology.- Regulation of rates of ethanol metabolism and liver [NAD+]/[NADH] ratio.- Free radical pathology in alcohol-induced liver injury.- Free radical mediated reactions and ethanol toxicity: Some considerations on the methodological approaches.- The molecular pathology of alcoholic liver disease: An overview.- Acetaldehyde adducts and excessive alcohol consumption.- Studies of a chemical measure of acetaldehyde adduct formation.- Ethanol-induced phosphorylation of cytokeratins in primary cultured hepatocytes.- Cloning and characterization of new alcohol dehydrogenase and aldehyde dehydrogenase isozymes.- Physiological role of aldehyde dehydrogenase (EC 1.2.1.3).- The alcohol dehydrogenase system in the rat: Comparison with the human enzyme.- Changes in the inducibility of a hepatic aldehyde dehydrogenase.- Class III alcohol dehydrogenases: Evidence for their identity with the glutathione-dependent formaldehyde dehydrogenases.- Genetic polymorphisms of alcohol metabolizing enzymes and their significance for alcohol-related problems.- Biochemical and genetic studies in ALDH1-deficient subjects.- Etiology of subgroups in chronic alcoholism and different mechanisms in transmitter systems.- Genetic linkage analysis: Simple solutions for complex traits?.- The changing view of ethanol's actions: From generalities to specifics.- The neurochemistry of ethanol tolerance.- The role of calcium channels in ethanol dependence.- Structural changes in the hippocampal formation and frontal cortex after long-term alcohol consumption and withdrawal in the rat.- Effect of ethanol on the rat medial septum nucleus: An in vivo study.- Liver tryptophan pyrrolase, brain 5-hydroxytryptamine and alcohol preference.- Alcohol abuse and fuel homeostasis.- Chronic alcoholism, malnutrition and folate deficiency.- Alcohol and protein turnover.- Role of thiamine deficiency in the pathogenesis of alcoholic peripheral neuropathy and the Wernicke-Korsakoff syndrome: An update.- Alcohol and cancer. A critical review.- Metabolism of ethanol and higher alcohols present in alcoholic drinks and their corresponding aldehydes in subcellular components of rat esophageal mucosa, and relevance for esophageal cancer in man.- Activation by human gastric mucosa of alimentary procarcinogens.- Effect of ethanol on gastrointestinal cell proliferation.- Chronic alcoholic skeletal myopathy: An overview.- Effects of ethanol on the immune system.- Workshop: Future Directions in Biomedical Research on Alcoholism.- Introductory remarks.- Biologic disorders in alcoholism as a basis for a public health approach: Policy implications.- What can we expect from animal models in alcoholism research? Limitations and relevance to the human condition.- Alcoholism research: Crystal ball or wishful thinking.- Alcohol and cancer. Where do we stand and where should we go?.- Chronic alcoholism: Subtypes useful for therapy and research.