Syndromes of Hormone Resistance on the Hypothalamic-Pituitary-Thyroid Axis

Preface. 1. Molecular basis of thyroid hormone action; P.M. Yen. 2. Tissues specific action of thyroid hormones: insights from knock out animal models; M. Plateroti, C. Angelin-Duclos, F. Flamant, J. Samarut. 3. Learning from nature's experiments on the thyroid hormone receptor; X-ray structures of RTH mutant ligand-binding domains; B.H. Sandler, J.D. Baxter, R.J. Fletterick. 4. Molecular pathogenesis of resistance to thyroid hormone; V.K.K. Chatterjee. 5. Syndromes of resistance to thyroid hormone: clinical aspects; D. Mannavola, P. Beck-Peccoz. 6. Resistance to thyroid hormone in the absence of mutations in the thyroid hormone receptor genes; S. Refetoff, P.M. Sadow, S. Reutrakul, K. Dennis, D. Mannavola, J. Pohlenz, R.E. Weiss. 7. Lessons learned from TR-beta mutant mice; F.E. Wondisford. 8. Towards the rational design of hormone analogs which complement receptor mutations; J.T. Koh, M.C. Putnam. 9. Multi-factorial regulation of in vivo action of TRbeta mutants. Lessons learned from RTH mice with a targeted mutation in the TRbeta gene; Sheue-yann Cheng. 10. The effect of vitamin A, retinoids and retinoid receptors on the hypothalamic-pituitary-thyroid axis; B.R. Haugen. 11. Pituitary resistance to thyroxine action due to a defect in the type 2 deiodinase; V.A. Galton. 12. Different forms of resistance to thyrotropin (TSH) action; L. Persani, D. Calebiro, T. de Filippis. Index.