Purine Metabolism in Man: Biochemistry and Pharmacology of Uric Acid Metabolism

of Volume 41B.- Gout.- The Kinetics of Intramolecular Distribution of 15N in Uric Acid Following Administration of 15N-Glycine: Preferential Labeling of N?(3+9) of Uric Acid in Primary Gout and a Reappraisal of the "Glutamine Hypothesis".- Hyperglutamatemia in Primary Gout.- Reduced Renal Ammoniagenesis in Primary Gout.- The Uptake of Glycine-14C into the Adenine and Guanine of DNA and Insoluble RNA of Human Leukocytes.- On the Problem of Hyperuricemia in Certain Physiological Stress Conditions.- Uric Acid Metabolism Following Acute Myocardial Infarction.- The Effect of Weight Reduction on Urate Metabolism.- Diet and Gout.- Effect of Ribomononucleotides Given Orally on Uric Acid Production in Man.- Relationship between Gout and Arterial Hypertension.- Studies on the Mechanism of Fructose-Induced Hyperuricemia in Man.- Observations of Altered Intracellular Phosphoribosylpyrophosphate (PP-Ribose-P) in Human Disease.- Human Erythrocyte Phosphoribosylpyrophosphate Content and "Generation" During a Constant Rate Infusion of Xylitol.- Diabetes and Uric Acid - A Relationship Investigated by the Epidemiological Method.- Metabolic and Glucose Load Studies in Uric Acid, Oxalic and Hyperparathyroid Stone Formers.- Observations Concerning the Incidence of Disturbance of Lipid and Carbohydrate Metabolism in Gout.- Gout and Hyperlipidaemia.- Lipid and Purine Metabolism in Benign Symmetric Lipomatosis.- An Integrative Hypothesis for the Renal Disease of Urate Overproduction.- Acute Intratubular Crystal Deposition Causing Permanent Renal Damage in the Pig.- Analysis of Treatment Results in Uric Acid Lithiasis with and without Hyperuricemia.- Isolation of a Red Pigment from the Uric Acid Calculi.- Concentration of Urate by Differential Diffusion: A Hypothesis for Initial Urate Deposition.- Experimental Hyperuricemia in Rats.- The Binding of Urate to Plasma Proteins.- Pharmacology.- Efficacy of Single Daily Dose Allopurinol in Gouty Hyperuricemia.- Withdrawal of Allopurinol in Patients with Gout.- Effect of Long-Term Allopurinol Administration on Serial GFR in Normotensive and Hypertensive Hyperuricemic Subjects.- Metabolic Studies of Thiopurinol in Man and the Pig.- Effects of Allopurinol and Oxipurinol on Pyrimidine Biosynthesis in Man.- The Molecular Basis for the Effects of Allopurinol on Pyrimidine Metabolism.- Purine and Pyrimidine Biosynthesis in Neurospora Crassa and Human Skin Fibroblasts. Alteration by Ribosides and Ribotides of Allopurinol and Oxipurinol.- Effects of Allopurinol and Oxonic Acid on Pyrimidine Metabolism in the Pig.- Ribonucleotides of Allopurinol and Oxipurinol in Rat Tissues and Their Significance in Purine Metabolism.- The Effect of Allopurinol on Oral Purine Absorption and Excretion in the Pig.- Allopurinol and Thiopurinol: Effect in vivo on Urinary Oxypurine Excretion and Rate of Synthesis of Their Ribonucleotides in Different Enzymatic Deficiencies.- Urinary Excretion of 6 Hydroxylated Metabolite and Oxypurines in a Xanthinuric Man Given Allopurinol or Thiopurinol.- Acute Renal Failure During Adenine Therapy in Lesch-Nyhan Syndrome.- Behavioural Changes During Adenine Therapy in Lesch-Nyhan Syndrome.- Treatment of Gout and Hyperuricaemia by Benzbromarone, Ethyl 2 (Dibromo-3,5 Hydroxy-4 Benzoyl)-3 Benzofuran.- The Pig As an Animal Model for Purine Metabolic Studies.- Influence of a Uricosuric Drug on Connective Tissue Metabolism.- The Synthesis and Immuno-Enhancing Activity of 3-Butylazathioprine.- Renal Handling of Urate.- The Clinical Significance of Hypouricemia.- Hypouricemia, Hypercalciuria, and Decreased Bone Density. A New Hereditary Syndrome.- Suppression of Uric Acid Secretion in a Patient with Renal Hypouricemia.- Evidence for a Urate Reabsorptive Defect in Patients with Wilson's Disease.- Reevaluation of the Pyrazinamide Suppression Test.- Evidence for a Post-Secretory Reabsorptive Site for Uric Acid in Man.- Uric Acid Excretion in Infancy.- Renal Handling of Uric Acid in Sickle Cell Anemia.- Hyperu