BCL 2 Protein Family: Essential Regulators of Cell Death

1. Homeostatic Functions of BCL?2 Proteins Beyond ApoptosisNika N. Danial, Alfredo Gimenez?Cassina and Daniel TonderaAbstractMitochondrial Energy MetabolismAutophagyProtein Quality Control and the Unfolded Protein ResponsePhysiologic Roles for BCL?2 Family Proteins in Cell Cycle Checkpoints, Differentiation and DNA Damage ResponseConclusion2. Alternative Functions of the BCL?2 Protein Family at the Endoplasmic ReticulumDiego Rojas?Rivera, Benjamin Caballero, Sebastian Zamorano, Fernanda Lisbona and Claudio HetzAbstractIntroductionThe BCL?2 Protein Family and the Unfolded Protein ResponseChronic ER Stress and BH3?Only ProteinsThe BCL?2 Protein Family and the Calcium RheostatAutophagy and the BCL?2 Protein Family of ProteinsConclusion3. BH3?Only Proteins and Their Efects on CancerThanh?Trang Vo and Anthony LetaiAbstractIntroductionCategories of BCL?2 Family Proteins and Their Apoptotic FunctionsRegulation of Various BH3?Only Proteins and Cell Stress SensingBH3?Only Proteins and Cancer DevelopmentBH3?Only Proteins and Chemotherapy Response and ResistanceBH3?only Mimetic DrugsConclusion4. Endoplasmic Reticulum Stress and BCL?2 Family MembersRoss T. Weston and Hamsa PuthalakathAbstractIntroductionUPR: The Good and the Evil SideUPR and BCL?2 Family MembersAutophagy, UPR and BCL?2 Family MembersConclusion5. Targeting Survival Pathways in LymphomaLuca Paoluzzi and Owen A. O'ConnorBCL?2 Family of Proteins and Cell DeathAbstractIntroductionPharmacologic Modulation of BCL?2 Proteins and ApoptosisBCL?2 Proteins and Non?Apoptotic Cell DeathConclusion6. The Interplay between BCL?2 Family Proteins and Mitochondrial Morphology in the Regulation of ApoptosisMaria Eugenia Soriano and Luca ScorranoAbstractIntroductionBCL?2 FamilyMitochondrial Shape and ApoptosisConclusion7. Noncanonical Functions of BCL?2 Proteins in the Nervous SystemHeather M. Lamb and J. MarieHardwickAbstractIntroductionExtending the Traditional View of BCL?2 Family ProteinsChallenging the Traditional BCL?2 Family ModelBCL?2 Family Proteins in the Nervous SystemWhen Anti?Death BCL?2 Proteins Become Pro?DeathWhen Pro?Death BCL?2 Proteins Protect NeuronsProtection Predicts New Functions with a SeizureBCL?2 Family Proteins Regulate Synaptic ActivityMitochondrial Dynamics in Neuronal FunctionConclusion8. Mitochondria on Guard: Role of Mitochondrial Fusion and Fission in the Regulation of ApoptosisMariusz KarbowskiAbstractIntroductionRegulation of Mitochondrial Fusion and FissionMitochondrial Network Dynamics and Cell HomeostasisRole of Mitochondrial Dynamics in Cell DeathMechanism of the OM Permeabilization: A Vital Role for Mitochondrial Fusion and Fission?Emerging Evidence for the Role of BCL?2 Family Proteins in the Regulation of Mitochondrial Network Dynamics in Healthy CellsConclusionIndex