A Systems Biology Approach to Blood

Part I: Basic Components.- Systems Hematology: An Introduction.- Quantification and Modeling of Stem Cell - Niche Interaction.- Angiogenesis: A Systems Biology View of Blood Vessel Remodeling.- Erythropoiesis: From Molecular Pathways to System Properties.- Systems Biology of Megakaryocytes.- Systems Biology of Platelet-Vessel Wall Interactions.- Systems Approach to Phagoycte Production and Activation: Neutrophils and Monocytes.- Part II: Physiological Processes.- Stochasticity and Determinism in Models of Hematopoiesis.- Systems Analysis of High-Throughput Data.- Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Control.- A Systems Biology Approach to Iron Metabolism.- Innate Immunity in Disease - Insights from Mathematical Modeling and Analysis.- Modeling Biomolecular Site Dynamics in Immunoreceptor Signaling Systems.- Structure and Function of Platelet Receptors Initiating Blood Clotting.- Part III: Clinical Applications.- Understanding and Treating Cytopenia through Mathematical Modeling.- Drug Resistance.- Etiology and Treatment of Hematological Neoplasms: Stochastic Mathematical Models.- Assessing Hematopoietic (Stem-) Cell Behavior during Regenerative Pressure.- Engineered Cell-Based Therapies: A Vanguard of Design-Driven Medicine.- Part IV: Epilogue.- A Systems Approach to Blood Disorders.- Index.