Animal Models for Stem Cell Therapy

PART I INTRODUCTION

1 Stem Cells--Are We Ready for Therapy?

Insa Schröder

2 Aurigon's Point of View on the Safety Assessment of Cell Based Therapies - An Experience Based on the Participation in 15 ATMPs Projects

Emmanuelle Cornali

PART II LIVER DISEASES

3 Pre-Conditioning of the Liver for Efficient Repopulation by Primary Hepatocyte Transplants

Petra Krause, Margret Rave-Fraenk, Hans Christiansen, Sarah Koenig

4 Age-Dependent Hepatocyte Transplantation for Functional Liver Tissue Reconstitution

Peggy Stock

5 Treatment of NASH with Human Mesenchymal Stem Cells in the Immunodeficient Mouse

Sandra Winkler, Bruno Christ

Takeshi Katsuda, Hayato Kurata, Rie Tamai, Agnieszka Banas, Tsuyoshi Ishii, Shumpei Ishikawa, and Takahiro Ochiya

7 A Mouse Model of Liver Injury to Evaluate Paracrine and Endocrine Effects of Bone Marrow Mesenchymal Stem Cells

Chiung-Kuei Huang, Soo Ok Lee, Jie Luo1, RongHao Wang, Qiang Dang, Chawnshang Chang

8 Animal Models to Test hiPS-Derived Hepatocytes in the Context of Inherited Metabolic Liver Diseases

Mathilde Dusséaux, Sylvie Darche and Hélène Strick-Marchand

9 Support of Hepatic Regeneration by Trophic Factors from Liver-Derived Mesenchymal Stromal/Stem Cells

Suomi M.G. Fouraschen, Sean R.R. Hall, Jeroen de Jonge and Luc J.W. van der Laan

PART III CARDIOVASCULAR DISEASES

10 Assessment of Functional Competence of Endothelial Cells from Human Pluripotent Stem Cells in Zebrafish Embryos

Valeria V. Orlova, Yvette Drabsch, Peter ten Dijke and Christine L. Mummery

Jixin Yang, Yanwei Su and Gail E. Besner

12 Exploring Mesenchymal Stem Cell-Derived Extracellular Vesicles in Acute Kidney Injury

Stefania Bruno, Giovanni Camussi

13 Angiogenesic Properties of Mesenchymal Stem Cells in a Mouse Model of Limb Ischemia

Sang Won Han

14 Methods to Assess Intestinal Stem Cell Activity in Response to Microbes in Drosophila melanogaster

Philip L. Houtz and Nicolas Buchon

PART IV CONNECTIVE AND CONTRACTILE TISSUE

15 Muscle Pouch Implantation: An Ectopic Bone Formation Model

Greg Asatrian, Le Chang, Aaron W. James

16 Bone Defect Repair in Mice by Mesenchymal Stem Cells

Sanjay Kumar

Reeva Aggarwal, Vincent J. Pompili and Hiranmoy Das

18 Application of Stem Cells for the Treatment of Joint Disease in Horses

Walther Brehm, Janina Burk, Uta Delling

19 Adipogenic Fate Commitment of Muscle-Derived Progenitor Cells: Isolation, Culture and Differentiation

Anne-Marie Lau, Yu-Hua Tseng, and Tim J. Schulz

20 Skeletal Muscle Stem Cells for Muscle Regeneration

Johnny Kim and Thomas Braun

PART V NEUROLOGICAL DISEASES

21 Bone Marrow Stromal Stem Cells Transplantation in Mice with Acute Spinal Cord Injury

Virginie Neirinckx, Bernard Rogister, Rachelle Franzen, Sabine Wislet-Gendebien

22 Histological Characterisation and Quantification of Cellular Events Following Neural and Fibroblast(-Like) Stem Cell Grafting in Healthy and Demyelinated CNS Tissue

Jelle Praet, Eva Santermans, Kristien Reekmans, Nathalie de Vocht, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Herman Goossens, Zwi Berneman, Niel Hens, Annemie Van der Linden, Peter Ponsaerts

23 Improvement of Neurological Dysfunctions in Aphakia Mice, a Model of Parkinson's Disease, after Transplantation of ES Cell-Derived Dopaminergic Neuronal Precursors

Sangmi Chung, Jisook Moon, Kwang-Soo Kim

24 Methods for Assessing Regenerative Responses of Neural Tissue

Steven W. Poser, Maria Adele Rueger, and Andreas Androutsellis-Theotokis

25 Mesenchymal Stem Cell-Based Therapy in a Mouse Model of Experimental Autoimmune Encephalomyelitis (EAE)

Annie C. Bowles, Brittni A. Scruggs, Bruce Bunnell

26 Analysis of the Neuroregenerative Activities of Mesenchymal Stem Cells in Functional Recovery after Rat Spinal Cord Injury

Akihito Yamamoto, Kohki Matsubara, Fumiya Kano, Kiyoshi Sakai

PART VI IMMUNEMODULATION BY STEM CELLS

Elena Gonzalez-Rey and Mario Delgado

28 Mesenchymal Stem Cells Attenuate Rat Graft-versus-Host Disease

Masayuki Fujino, Ping Zhu, Yusuke Kitazawa, Ji-Mei Chen, Jian Zhuang, and Xiao-Kang Li

29 Assessment of Anti-Donor T Cell Proliferation and Cytotoxic T Lymphocyte-Mediated Lympholysis in Living Donor Kidney Transplant Patients

Aruna Rakha, Marta Todeschini, Federica Casiraghi

30 Modulation of Autoimmune Diseases by iPS Cells

Fengyang Lei, Rizwanul Haque, Xiaofang Xiong and Jianxun Song

31 A Chimeric Mouse Model to Study Immunopathogenesis of HCV Infection

Moses T. Bility, Anthony Curtis and Lishan Su