Chemogenomics: Methods and Applications

1. Organizing Bioactive Compound Discovery in Target FamiliesH. Peter Nestler2. Compound Library Design for Target FamiliesK. V. Balakin, Y. A. Ivanenkov, and N. P. Savchuk3. Targeting the PurinomeJeremy M. Murray and Dirksen E. Bussiere4. Cofactor ChemogenomicsRatna Singh and Andrea Mozzarelli5. Chemogenomics with Protein Secondary Structure MimeticsGarland R. Marshall, Daniel J. Kuster, and Ye Che6. Database Systems for Knowledge-Based DiscoverySarma A.R.P. Jagarlapudi and Radha Kishan K.V.7. Knowledge-Based Virtual Screening: Application to the MDM4/p53 Protein-Protein InteractionEdgar Jacoby, Andreas Boettcher, Lorenz M. Mayr, Nathan Brown, Jeremy L. Jenkins, Joerg Kallen, Caroline Engeloch, Ulrich Schopfer, Pascal Furet, Keiichi Masuya, and Joanna Lisztwan8. Off-Target Networks Derived from Ligand Set SimilarityMichael J. Keiser and Jérôme Hert9. Chemogenomic Analysis of Safety Profiling DataJosef Scheiber and Jeremy L. Jenkins10. Network and Pathway Analysis of Compound-Protein InteractionsRichard J. Brennan and Svetlana Bureeva11. The Flexible Pocketome Engine for Structural ChemogenomicsRuben Abagyan and Irina Kufareva12. Structure-Based Chemogenomics: Analysis of Protein Family LandscapesBernard Pirard13. Hypothesis-Driven ScreeningUlrich Schopfer, Caroline Engeloch, Frank Höhn, Hervé Mees, Jennifer Leeds, Fraser Glickman, Günther Scheel, Sandrine Ferrand, Peter Fekkes, and Martin Pfeifer