The 4-Quinolones: Anti Bacterial Agents in Vitro: Antibacterial Agents in Vitro

1 Quinolones as Broad-Spectrum Agents.- 2 Effects of Physiological Cation Concentration on 4-Quinolone Absorption and Potency.- 3 The Influence of Oxygen upon Bactericidal Potency.- 4 Interactions of 4-Quinolones with Other Agents - the Importance in Assessing Practical Antibacterial Potency.- 5 Molecular Effects of 4-Quinolones upon DNA Gyrase.- 6 Mechanisms of Killing of Bacteria by 4-Quinolones.- 7 Use of an in vitro DNA Strand-Breakage Assay to Monitor Compound Interactions with DNA Gyrase.- 8 Comparisons of DNA Gyrases from Different Species.- 9 Structure-activity Relationships of Fluoro-4-Quinolones.- 10 Aspects of Quinolone-DNA Interactions.- 11 Selective Toxicity: the Activities of 4-Quinolones against Eukaryotic DNA Topoisomerases.- 12 In vitro Genotoxity Assessment and the Effects of 4-Quinolones upon Human Cells.- 13 Mechanisms of Bacterial Resistance to 4-Quinolones.- 14 In vitro and in vivo Mutation Frequencies to Resistance - do they Correlate in the Long Term?.- 15 Measurement of the Frequency of Mutation to Resistance - the Importance of Testing under Physiological Conditions.- 16 Plasmid-borne Resistance to 4-Quinolones - a Real or an Apparent Absence?.- Poster Presentations.- Anaerobiosis and staphylococcal resistance to certain 4-quinolones.- Gram Negative Mutants Resistant to 4-Quinolones: Are they Competent Pathogens?.- Quinolone-Resistant E. Coli Mutants Overproduce a 60 kDa Protein Highly Homologous to GroEL.