Molecular and Cellular Mechanisms of Mutagenesis

Section I Cellular Responses to Mutagenic Agents.- 1 Mutagenesis from a Chemical Perspective: Nucleic Acid Reactions, Repair, Translation, and Transcription.- 2 Regulation and Functions of Escherichiacoli Genes Induced by DNA Damage.- 3 Methylation-Instructed Mismatch Correction as a Postreplication Error Avoidance Mechanism in Escherichiacoli.- 4 Cellular Defense Mechanisms Against Alkylation of DNA.- 5 Cellular Responses to Mutagenic Agents: A Summary and Perspective.- Section II Mutagenesis at Specific Sites.- 6 Mechanisms of UV Mutagenesis in Yeast.- 7 Site-specific Mutagenesis: A New Approach for Studying the Molecular Mechanisms of Mutation by Carcinogens.- 8 Single-Stranded Gaps as Localized Targets for In Vitro Mutagenesis.- 9 Mutagenesis at Specific Sites: A Summary and Perspective.- Section III Mutators, Antimutators, and DNA Replication Errors.- 10 Polymerase Infidelity and Frameshift Mutation.- 11 In Vitro Replication of Mutagen-Damaged DNA: Sites of Termination.- 12 Depurination of DNA as a Possible Mutagenic Pathway for Cells.- 13 Passive Polymerase Control of DNA Replication Fidelity: Evidence Against Unfavored Tautomer Involvement in 2-Aminopurine-Induced Base-Transition Mutations.- 14 Mutators, Antimutators, and DNA Replication Errors: A Summary and Perspective.- Section IV Transposable Elements and Spontaneous Mutation.- 15 Low Level and High Level DNA Rearrangements in Escherichiacoli.- 16 Mutants of Escherichiacoli K12 Which Affect Excision of Transposon TN10.- 17 Gene Conversion: A Possible Mechanism for Eliminating Selfish DNA.- 18 Transposons and Illegitimate Recombination in Prokaryotes: A Summary and Perspective..- Section V Chromosomal and Nonchromosomal DNA.- 19 Mutagenesis and Repair in Yeast Mitochondrial DNA.- 20 Alterations in Chromatin Structure During DNA Excision Repair.- 21 New Approaches to DNA Damage and Repair: The Ultraviolet Light Example.- 22 Chromosomal and Nonchromosomal DNA: A Summary and Perspective.- Section VI Mutagenesis: Future Directions.- 23 Comparison of the Induction of Specific Locus Mutations in Wild-Type and Repair-Deficient Strains of NeurosporaCrassa.- 24 Mammalian Mutagenesis: Future Directions.- 25 Perspectives in Molecular Mutagenesis.- Contributors.