Genetics and Evolution of Aging

Preface. Part One: General Perspectives on Aging. The Janiform genetics of aging: M.R. Rose, C.E. Finch. Evolutionary mechanisms of senescence; B. Charlesworth. Multation-selection balance and the evolution of senescence; A.G. Clark. Pathogen evolution within host individuals as a primary cause of senescence; G. Bell. Part Two: Diversity of Aging. Comparative approaches to the study of senescence: Bridging genetics and phylogenetics; D.E.L. Promislow, M. Tatar. The genetics of aging in the yeast Saccharomyces cerevisiae; S.M. Jazwinski. Evolutionary senescence in plants; D.A. Roach. Comparing mutants, selective breeding, and transgenics in the dissection of aging processes of Caenorhabditis elegans; T.E. Johnson, P.M. Tedesco, G.J. Lithgow. New model systems for studying the evolutionary biology of aging: Crustacea; D. Reznick. Part Three: Aging in Drosophila. Evolution of aging: Testing the theory using Drosophila; L. Partridge, N.H. Barton. Population density effects on longevity; J.L. Graves, L.D. Mueller. Evolution of delayed reproductive senescence in male fruit flies: Sperm competition; P.M. Services, A.J. Fales. Genetic and environmental factors regulating the expression of an extended longevity phenotype in a long-lived strain of Drosophila; R. Arking, S.P. Dudas, G.T. Baker III. The effect of superoxide dismutase alleles on aging on Drosophila; R.H. TylerDAGGER, H. Brar, M. Singh, A. Latorre, J.L. Graves, L.D. Mueller, M.R. Rose, J. Ayala. Use of recombinant inbred lines to map genes of aging; L.K. Dixon. The effects of enhanced expression of elongation factor EF-1alpha on lifespan in Drosophila melanogaster. IV. A summary of three experiments; S.C. Stearns, M. Kaiser. Two-dimensional protein electrophoretic analysis of postponed aging in Drosophila; J.E. Fleming, G.S. Spicer, R.C. Garrison, M.R. Rose. Part Four: Aging in Mammals. Longevity and fecundity in eutherian mammals; R. Holliday. Thoughts on the evolutionary basis of dietary restriction; A. Richardson, M.A. Pahlavani. Genetic control of retroviral disease in aging wild mice; M.B. Gardner. Genetics of life span in mice; E.J. Yunis, M. Salazar. Genes of the major histocompatibility complex and the evolutionary genetics of lifespan; M.D. Crew. Genetic influences on glucose neurotoxicity, aging, and diabetes: a possible role for glucose hysteresis; C.V. Mobbs. Genetic heterogeneity of gene defects responsible for familial Alzheimer disease; R. Tanzi, S. Gaston, A. Bush, D. Romano, W. Pettingell, J. Peppercorn, M. Paradis, S. Gurubhgavatula, B. Jenkins, W. Wasco. Abiotrophic gene action in Homo sapiens: Potential mechanisms and significance for the pathobiology of aging; G.M. Martin. Antagonistic pleiotropy, mutation accumulation, and huiman genetic disease; R.L. Albin.