Oxygen-Ozone Therapy: A Critical Evaluation

1. A brief historical review. 2. How I came to study ozonetherapy: an odyssey with no end in sight. 3. Ozone in nature. 4. Physico-chemical properties of ozone. 5. Ozone toxicity: biological risk, toxicology and first aid. 6. The ozone generator. 7. How to check ozone concentrations. 8. Solubility of ozone in water and preparation of ozonized water and oil. 9. Preliminary basis for understanding ozone reactivity and the potential risks of ozonetherapy. 10. How is oxidative stress assessed? 11. Is there any justification for using ozonetherapy in human pathologies caused or worsened by free radicals? 12. The antioxidant system and the defense system against ozone. 13. How does ozone act? 14. What happens in the intracellular environment after blood ozonization? 15. Are blood lipoproteins oxidized after ozonization? 16. How is ozone administered? 17. Extracorporeal blood circulation versus O2-O3 (EBOO). 18. Quasi-total body exposure to O2-O3 (BOEX). 19. Rectal insufflation of O2-O3 (RI). 20. The potential toxicity and mutagenicity of ozone. 21. Side effects and contraindications of ozonetherapy. 22. The adaptation to chronic oxidative stress (COS). 23. How to evaluate Ozonetherapy? 24. Ozonetherapy in various pathologies. 25. How important is the placebo effect in ozonetherapy? 26. Ozonetherapy in dentistry. 27. Ozonetherapy in cosmetology. 28. Ozonetherapy in veterinary medicine. 29. Ozone as doping in athletes. 30. Ozone as a rejuvenating agent! 31. Ozone as a drinking water disinfectant. 32. Ozone disinfection to prevent nosocomial infections. 33. Can ozone be useful for banked blood or fresh frozen plasma? 34. Is there any way to substitute ozonization of blood? 35. Hyperbaric oxygen therapy (HOT) versus ozonetherapy. 36. Acute care during or after ozonetherapy. 37. Orthodox medicine versus complementary medicine: a conflict that may be resolved with appropriate research. 38. Does ozonetherapy have a future in medicine? 39. Appendix: The optimized procedure of O3-AHT. References. Index