Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease

Mitochondrial ROS and Apoptosis.- Dopamine Metabolism and Reactive Oxygen Species Production.- The Consequences of Damaged Mitochondrial DNA.- The role of chronic inflammation in the etiology of Parkinson's disease.- Ion-Catalyzed Reactive Oxygen Species in Sporadic Models of Parkinson's Disease.- Toxin Mediated Complex I Inhibition and Parkinson's Disease.- Parkinson Disease-Associated Mutations Affect Mitochondrial Function.- PARKIN/PINK1 Pathway for the Selective Isolation and Degradation of Impaired Mitochondria.- Mitochondrial Therapeutic approaches in Parkinson's Disease.- Altering Mitochondrial Fusion and Fission Protein Levels Rescues Parkin and PINK1 Loss-of-Function Phenotypes.- Early Nicotine Exposure is Protective in Familial and Idiopathic Models of Parkinson's Disease.- Transcription Modulation of Mitochondrial Function and Related Pathways as a Therapeutic Opportunity in Parkinson's Disease.- Delivery of Biologically Active Molecules to Mitochondria.