A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

1. Introduction.- Part I: Biology.- 2. "Non-model" species for eco and human health risk assessment.- 3.The fish embryo as a model for eco-toxicology and other potential models.- 4.Invertebrates/Plants.- 5.Behavioral/Neurobehavioral linkages to AOPs.- 6. Species extrapolation - common pathways etc.- 7. Life History Evolution, incorporating evolutionary processes into AOPs to extrapolate.- Part II: Incorporating Biology into AOPs.- 8.Use of HTS assays to infer MIEs.- 9. AOP development: how to infer and define KER.- 10. The development of quantitative AOPs.- Part IV: Incorporating Modeling into AOPs.-11.Computational approaches (network science, etc) in AOPs: linking molecular datasets.- 12.Computational approaches : Dynamic Energy Budgets.- 13. Modeling approaches in AOPs: extrapolation from individual to population.- 14. Modeling approaches that augment AOPs: GUTS, QSAR, TKTD PBTKTD.- 15. Exposure science and other stressors? How to incorporate.- 16. AOP as an organizing framework and implications for biological science-AOP evolution.- 17. Use and acceptance of AOPs for regulatory applications, use of AOPs in human risk assessment, and legislation.