Molecular Mechanisms of Notch Signaling

Preface

Contributors

Part 1 - Introduction

Benedetto Daniele Giaimo and Tilman Borggrefe

Part 2 - Molecular mechanisms of receptor/ligand interactions

2.      Structural insights into Notch receptor-ligand interactions

Penny Handford, Boguslawa Korona, Richard Suckling, Christina Redfield and Susan Lea

3.      The Molecular Mechanism of Notch Activation

Klaus N. Lovendahl, Stephen C. Blacklow and Wendy R. Gordon

4.      Regulation of Notch Function by O-Glycosylation

Beth M. Harvey and Robert S. Haltiwanger

Udi Binshtok and David Sprinzak

6.      Endocytic trafficking of the Notch receptor

Björn Schnute, Tobias Troost and Thomas Klein

Part 3 - Intracellular signaling mechanisms

7.      The Notch Interactome: complexity in signaling circuitry

Diana M. Ho, K. G. Guruharsha and Spyros Artavanis-Tsakonas

8.      Integration of Drosophila and Human Genetics to understand Notch signaling related diseases

Shinya Yamamoto and Jose L. Salazar

9.      Mechanisms of non-canonical signaling in health and disease: Diversity to take therapy up a Notch?

Victor Alfred and Thomas Vaccari

Diana Bellavia, Saula Checquolo, Rocco Palermo and Isabella Screpanti

11.  Notch and neurogenesis

Anna Engler, Runrui Zhang and Verdon Taylor

12.  Notch and stem cells

13.  Oscillatory control of Notch signaling in development

Ryoichiro Kageyama, Hiromi Shimojo and Akihiro Isomura

Franz Oswald and Rhett A. Kovall

Part 4 - Disease links and therapeutics

15.  Notch and senescence

Matthew Hoare and Masashi Narita

Fabian Tetzlaff and Andreas Fischer

17.  Notch and T cell function - a complex tale

Jyothi Vijayaraghavan and Barbara A. Osborne

18.  Notch in leukemia

Anna C. Gormley, Qing Wang and Mark Chiangs