Nitroimidazoles: Chemistry, Pharmacology, and Clinical Application

The Pharmacology and Toxicology of 5-Nitroimidazoles.- Nitroimidazole Chemistry I. Synthetic Methods.- Chemical Properties and Reaction Mechanisms of Nitroimidazoles.- In vivo Testing of Radiosensitizers.- Nitroimidazoles as Hypoxia-Mediated Drugs in Cancer Chemotherapy.- Metronidazole and Misonidazole in Cancer Chemotherapy: Effect of Cell Density on Drug Activity.- Metabolism of Nitroimidazoles.- Mechanism of Cytotoxicity of Nitroimidazoles.- Nitroimidazoles as Antiparasitic Agents.- Resistance to 5-Nitroimidazoles in Pathogenic Microorganisms.- Pharmacokinetics of Nitroimidazoles.- The Clinical Pharmacology of Misonidazole in Radiation Therapy Oncology Group Trials.- Metronidazole and Misonidazole: Absence of Cytogenetic Effects in a Euoxic Bacterial and a Mammalian Cell System in vitro.- Investigations with Nitroimidazoles in Clinical Oncology.- Pharmacokinetic and Therapeutic Studies with Misonidazole and Desmethylmisonidazole in man.- List of Participants.