Mass Spectrometry in the Biological Sciences: A Tutorial

I: Instrumentation for Mass Analysis and Detection.- 1. Sectors and Tandem Sectors.- 2. Hybrid Tandem Mass Spectrometry.- 3. Triple Quadrupole Mass Spectrometry.- 4. Quadrupole Ion Trap Mass Spectrometers for Studies of Biomolecules.- 5. Fourier Transform Mass Spectrometry: Features, Principles, Capabilities, and Limitations.- 6. Time-of-Flight Mass Spectrometers.- 7. Ion Detection in Mass Spectrometry.- II: Methods in Mass Spectrometry.- 8. Electrospray Mass Spectrometry.- 9. Laser Desorption Mass Spectrometry. Part I: Basic Mechanisms and Techniques.- 10. Laser Desorption Mass Spectrometry. Part II: Performance and Applications of Matrix-Assisted Laser Desorption/Ionization of Large Biomolecules.- 11. Laser Desorption, Chemical Ionization, and Laser Desorption/Chemical Ionization Applications with Fourier Transform Mass Spectrometry.- 12. Plasma Desorption Mass Spectrometry: Principles and Applications to Protein Studies.- 13. Continuous Flow Fast Atom Bombardment Mass Spectrometry in Analytical Biochemistry.- 14. Combined Liquid Chromatography/Mass Spectrometry (LC/MS): A Review.- 15. Combined Supercritical Fluid Chromatography/Mass Spectrometry (SFC/MS).- 16. Determination of Biomolecules by Using Liquid Chromatography and Thermospray Mass Spectrometry: from Penicillins to Peptides.- 17. Neutralization-Reionization Mass Spectrometry: Fundamental Studies and Analytical Applications.- 18. Some Applications of the Quantum-Mechanical Semiempirical Methods to the Gas-Phase Chemistry of Bio-Organic Ions.- III: Applications to Biomolecules.- 19. Characterization of Human Hemoglobin Variants by Mass Spectrometry.- 20. Detection of Post-Translational Modification of Proteins by Mass Spectrometry.- 21. Manipulation of Experimental Variables for FAB MS and MS/MS to Facilitate Identification of a Post-Translational Modification in Rabbit Elongation Factor l?.- 22. Use of FAB MS and MS/MS in the Structural Determinations of Cockroach Neuropeptides.- 23. The Mass Spectrometric Determination of Retro-Inverso Linear Peptides.- 24. Mass Spectrometry in Studies of O-Linked Glycopeptides Isolated from Natural and Recombinant Glycoproteins.- 25. Nucleosides and Oligonucleotides: Structures and Principles of Reactivity from Mass Spectrometry.- 26. Application of Tandem Mass Spectrometry to Carcinogen-Modified Nucleosides.- 27. Structure Determination of Lipids: Comparison of Classical Methods and New Approaches Involving Charge-Remote Fragmentation.- 28. The Use of FAB-MS of Cellular Lipids for the Characterization of Medically Important Bacteria.- 29. Structural Analysis of Phosphatidylinositol from Carrot Cell Membranes by Fast Atom Bombardment and Tandem Mass Spectrometry.