Mathematical Modeling and Scale-Up of Liquid Chromatography: With Application Examples

Introduction.- Literature Review.- General Multicomponent Rate Models for Column Liquid Chromatography.- Numerical Solutions and Computer Software with Graphical User Interface.- Mass Transfer Effects.- Interference Effects in Multicomponent Chromatography.- System Peaks In Multicomponent Elution.- Multicomponent Adsorption with Uneven Saturation Capacities.- Modeling of Size Exclusion Chromatography.- Modeling of Ion-Exchange Chromatography with Steric Mass-Action Isotherm.- Modeling of Chromatography with Cored Beads - Advantages And Limitations.- Modeling of Affinity Chromatography.- Modeling of Multicomponent Gradient Elution.- Multicomponent Radial Flow Chromatography.- Parameter Estimation and Parameter Sensitivity Analysis.- Scale-Up Methods and Examples.