The role of Adrenomedullin in implantation and Fetoplacental growth: Adrenomedullin Sustains Pregnan

The purpose of present study was to investigate the role of ADM in early implantation and to understand better the mechanism involved in trophoblast invasion during implantation on uterine endometrium. The present work helped us to have a better comprehension on ADM and ADM antagonistic role. Therefore we demonstrated the importance of endogenous ADM during early implantation and its role in regulation of apoptosis in uteroimplantation development. In accordance to our previous reports it was acknowledged that endogenous ADM plays a significant involvement in reproductive functions and in development of fetus during pregnancy and moreover various studies have shown that endogenous ADM expressions and its plasma levels throughout the pregnancy but there was no particular in vivo and invitro studies by inhibition of endogenous ADM function during day start of implantation and the placentation. On these grounds, the present study was designed to evaluate the involvement of endogenous ADM during implantation and in control of blastocyst proliferation through apoptosis.