The NeuroProcessor: An Integrated Interface to Biological Neural Networks

1 Introduction. 1.1 Overview of the Book. 2 Recording from Biological Neural Networks. 2.1 The Neuron. 2.2 Interfacing Neurons Electrically. 2.3 Neuronal Probes for Extracellular Recording. 2.4 Recording from Cultured Neural Networks. 2.5 Typical Multi-Electrode Recording Setup. 2.6 Recorded Signal Information Content. 3 The Neuroprocessor. 3.1 Datarate Reduction in Neuronal Interfaces. 3.2 Neuroprocessor Overview. 4 Integrated Front-end for Neuronal Recording. 4.1 Background. 4.2 NPR01: First Front-end Generation. 4.3 NPR02: Analog Front-end with Sprike/LFP Separation. 5 NPR03: Mixed-Signal Integrated Front-end for Neuronal Recording. 5.1 Overview. 5.2 NPR03 Architecture. 5.3 Host Interface. 5.4 NPR03 Channel. 5.5 Analog-to-Digital Converter. 5.6 Integrated Preamplifier with DC Blocking. 5.7 NPR03 Measurements. 5.8 An NPR03 -Based Miniature Headstage. 5.9 A Novel Opamp for the Front-end Preamplifier. 5.10 Conclusions. 6 Algorithms for Neuroprocessor Spike Sorting. 6.1 Introduction. 6.2 Spike Sorting in a Neuroprocessor. 6.3 Spike Sorting Algorithms. 6.4 Detection and Alignment Algorithms. 7 MEA on Chip: In-Vitro Neuronal Interfaces. 7.1 Prototype Sensor. 7.2 Temperature sensor and heater. 7.3 Post-Processing and Bath Formation. 7.4 Conclusions and Future Work. 8 Conclusions. 8.1 Research Contributions. 8.2 Future Work. A NPR02 Technical Details. A.1 NPR02 Preamp Sizing. A.2 NPR02 Testboard Output Channel. B NPR03 Technical Details. B.1 NPR03 Instruction Set. B.2 NPR03 Registers. B.3 NPR03 Preamp Sizing. B.4 Measurements of Additional NPR03 Channel Circuits. References. Index.