Non-Biological Complex Drugs: The Science and the Regulatory Landscape

Introduction: Defining the position of Non-Biological Complex Drugs.- Polymeric micelles.- Liposomes: the science and the regulatory landscape.- Glatiramoids.- Iron carbohydrate complexes: characteristics and regulatory challenges.- Drug Nanocrystals.- Analytical methods for determining the size (distribution) in parenternal dispersions.- NBCD Pharmacokinetics and Bioanalytical Methods to Measure Drug Release.- Low Molecular Weight Heparins, Biological Drugs close to Non-Biological Complex Drugs.- Nanoparticle Albumin-Bound Anticancer Agents.- The EU regulatory landscape of Non-Biological Complex Drugs.- What did we learn? What can we expect in the future? Concluding remarks and outstanding issues.